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chromatin landscape at DSB Gaelle legube

Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin. Oour research is performed at the MCD unit within the CBI in Toulouse, France.

LATEST NEWS

Congrats to Benjamin!

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November 2025

The article from Benjamin Le Bozec, former PhD student, supervized by Nadine is out in Mol Cell! In this work, we show that DSB in active loci (TC-DSB) can relocate to the nucelar periphery in human cells, for homologous recombination repair, and that this is under the control of the cirdadian clock.

Time to celebrate

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July 2025

It has been a while since we had gathered all together! We had many things to celebrate! So it was a good excuse to organize a BBQ party.

Congrats to Laure Guitton-Sert !

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August 2025

Laure Guitton-Sert (former post-doc in our team) has been recruited as a lecturer ("maîtresse de conférence") at the University of Toulouse. She will join to Didier Trouche's team at the CBI.

Congrats to Ikrame!

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July 2025

Ikrame Lazar has been recruited as a lecturer ("maîtresse de conférence") at the University of Toulouse. She will remain in our team.

"Face Cam" 

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August 2025

Our local CNRS branch, made a short video in which Gaëlle explains our recent findings and the impact it could generate for medical research.

Congrats to Florian and Emma !

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May 2025

Two former PhDs of the team share a co-first authorship on the story where we show that RNA:DNA hybrids at DSBs orginiated from pre-existing RNA and transcriptional repression

When RNA gets involved in DSB repair

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July 2025

CNRS biologie highlighted our recenlty published article with content tailored for the general public.

Anne-Laure Finoux is recruited as an engineer

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December 2024

Anne-Laure Finoux has been recruited at the CNRS as a research engineer ("ingénieure d'étude"). She works on the genSCAN platform and also in our team. We are glad to have her back!

RECENT ARTICLES

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November 2025

This article in Mol Cell shows that, as persistent breaks in yeast, or heterochromatic breaks in drosophila, some DSBs (TC-DSBs, induced in active loci) can reloacte to the nuclear periphery in human cells.  At the nuclear enveloppe they are anchored via a protein of the LINC complex, Sun1 but not via Sun2. This process is under the control of PERIOD proteins, that are key factors ensuring circadian oscillations, and we report that consequently, TC-DSB repair is regulated by the cirdadian clock.

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May 2025

This article in Nature Cell Biology shows that RNA:DNA hybrids, rather than R-loops, are stabilized at DSBs. Moreover, their formation results from the asymmetric hybridization of pre-existing RNA to the non-resected DNA strand as a consequence of transcriptional repression.

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October 2023

This article Nature shows that a novel chromatin compartment forms in response to DSB induction.

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